Methyldrene 25 is an ephedra dietary supplement that is advertised as an “Extra Potent Fat Burner.”
Sold by Cloma Pharma Laboratories, Methyldrene 25 diet pills are purported to burn fat fast and provide extreme energy. This supplement contains 25 mg of ephedra extract along with 16 other ingredients to support weight loss and appetite control.
According to online retailers, this supplement works best when taken before physical activity. It can promote a boost of energy, increased endurance and stimulates fat loss through a thermogenic effect.
How does this product work and is Methyldrene 25 with ephedra legal? In this review, we will discuss the ingredients found in this supplement, how they work, purported benefits, potential side effects and where to legally buy this product. Click here to buy ephedra supplements online legally without a prescription.
What is Methyldrene 25?
Methyldrene 25 is marketed as an “Original Ephedra ECA stack”, designed to provide the fat burning benefits of ephedra in combination with caffeine and aspirin.
This stack is purported to:
- Burn fat fast
- Promote extreme energy
- Enable fast-acting results
- Provide extra potency
According to the Ephedra Warehouse website, “Methyldrene 25 diet pills are designed to help increase metabolism as well as decrease appetite.”
This product contains a number of stimulant ingredients that can increase the rate your body burns calories, help you feel less hungry throughout the day and give you sustained energy and mood enhancement.
Like other forms of ephedra supplements, this product is said to increase thermogenesis, which is the rate at which you break down calories and fat to convert into heat. By modestly increasing your thermogenic activity, research suggests that ephedra extracts can boost caloric expenditure between 5-10% over short periods of time.
Methyldrene 25 Ephedrine Content
The Methyldrene supplement provides 25mg of a legal Ephedra extract in each serving. You may be wondering, isn’t ephedra banned in dietary supplements by the US FDA?
In 2004, the Food and Drug Administration ruled that all versions of ephedrine-based dietary supplements had to be recalled and removed from the market. They decided that this ingredient posed an unreasonable risk of injury or illness and was too dangerous to allow in weight loss products.
Ephedrine is the main active alkaloid found the Ephedra Sinica plant that was used in fat burner supplements. It produces the stimulatory effects of this herb that can boost metabolism and thermogenic activity.
However, not all species of the ephedra plant that are used medicinally have been found to contain this alkaloid. Ephedra sub-species are found around the world, some more potent than others.
One of the most potent forms of ephedra is the Chinese ephedra (Ephedra sinica) more commonly known as Ma Huang. This species of ephedra contains numerous stimulating alkaloids including ephedrine, pseudoephedrine, norephedrine, and others.
It is these alkaloids that are deemed to be the most beneficial weight-loss and energy boosting effects.
However, the species of ephedra found in the Methyldrene 25 product comes from the viridis plant which contains little to no alkaloids. It does contain a small amount of pseudoephedrine, but no ephedrine components .
Species that do contain ephedrine include but are not limited to:
- Ephedra sinica
- Ephedra equisetina
- Ephedra intermedia
- Ephedra distachya
- Ephedra regeliana
Because Methyldrene does not contain real ephedrine alkaloids, it is legal to sell as an over-the-counter dietary supplement. However, this also means it is less effective for fat loss compared to original formulation ECA stacks that did include this now-banned alkaloid.
The makers of Methyldrene 25 have instead added a number of alternative ingredients that can promote stimulant effects and replace some of the mechanism of action attributed to ephedrine. For example, yohimbine, theobromine, synephrine and cayenne extract are all believed to provide similar effects.
These ingredients are also purported to be safer than ephedrine, although they can cause side effects of their won. It is always recommended that individuals taking a product for the first time start at the lowest dosage to determine its effects.
Methyldrene 25 Ingredients List
Methyldrene 25 is composed of a 375mg ECA proprietary blend with 25mg ephedra viridis leaf extract. E.viridis is an American species of the ephedra plant that has little to no ephedrine but does contain small amounts of pseudoephedrine. 
Other ingredients in this blend include 250 mg of caffeine anhydrous and 100 mg of White Willow Bark powder providing 25% Salicins.
White willow bark is a natural analgesic commonly used in place of aspirin in dietary supplements. It is a herbal source of salicins, which have a similar effect to the active ingredient in Aspirin.
This supplement also provides 2mg of Vitamin B6 (as pyridoxine HCL), 6mg of Vitamin B12 (as cyanocobalamin) and 30mch of Chromium (as chromium picolinate).
Other ingredients listed on the label for this product include 397 mg of a proprietary blend referred to as the Methyldrene Fat-Burning Support System. This blend is composed of undisclosed amounts of:
- Citrus aurantium fruit extract (30% synephrine)
- Panax ginseng root (4% ginsenosides)
- Ginger Root
- Hoodia Gordonii 20:1 Stem Extract
- Cayenne Fruit 40,000 Heat Units
- Green tea extract (guaranteed 95% polyphenois)
- Coco Bean Extract (20% Theobromine)
- Yohimbine Bark Extract (8% Yohimbine)
- Griffonia Seed Standardized Extract (Source of 5-HTP)
Instructions for use are to take one capsule following meals, not exceeding two capsules daily. It is recommended to take one capsule in the morning with breakfast and a second capsule in the afternoon with lunch.
Do not take this product within 6 hours of going to bed as it can interfere with your ability to fall asleep at night.
Methyldrene 25 Elite
Another similar product known as Methyldrene 25 Elite Stack is also available, but with a different color scheme.
This product contains a formulation with some more powerful ingredients but may be too stimulating for some users. If you have a high tolerance to stimulants, this product may be a better choice for you.
This supplement includes some additional ingredients on top of those mentioned in the original formal product. The ingredients list in Methyldrene 25 Elite include:
- Vitamin B6 2mg
- Vitamin B12 6mcg
- Chromium Picolinate 30mcg
- Caffeine Anhydrous 250mg
- Ephedra Extract 25mg
- White Willow Bark 100mg
- Methylsynephrine 20mg
- Phenylethylamine HCL 20mg
- Citrus Aurantium 100mg
- Yohimbine HCL 1.5mg
- Bauhinia Purpurea L. 10.mcg
- Panax Ginseng 100mg
- Bacopa Monnieri 5mg
- Cayenne 25mg
- MCT Oil Powder 25mg
- Black Pepper Extract 5mg
Powdered MCT is a medium chain triglyceride purported to have a positive impact on cognitive focus and weight management. Coconut oil is one primary source of MCT oil.
Bacopa Monnieri (Brahmi, Water hyssop) is a nootropic herb primarily used in traditional Ayurvedic herbal medicine to enhance cognition, as well as to reduce anxiety or nervousness
Bauhinia Purpurea – this product is native to Asia and belongs to the orchid family of plants, an herbal ingredient primarily known as an analgesic and antibacterial product that also contains amino acids.
Mechanism of Action
Given the large number of ingredients in the Methyldrene supplement stacks, defining the mechanisms of action is complex.
Many of these ingredients may have synergistic effects that have not been measured in clinical studies. This specific combination of ingredients has also not been researched in any clinical trials.
The primary mechanism of action for the ingredients in this supplement is to stimulate the central nervous system and promote a higher basal metabolic rate.
Components such as Citrus Aurantium, caffeine, synephrine and cayenne extract have all been shown in research studies to promote lipolysis, which is the burning of fat.
This combination of ingredients may also accelerate heart rate, increase circulation, enhance oxygenation and promote a burst of energy that will last for several hours. The same mechanisms can contribute to appetite suppression, greater motivation, as well as increased restlessness and fidgeting, which can also cause you to burn more calories.
The original ECA stack supplements that contained ephedrine alkaloids worked because ephedrine was a beta-2 receptor agonist and exhibited a similar effect in the body as the natural hormone adrenaline.
P-synephrine is similar in its molecular structure and mechanism of action to ephedrine, which makes it one of the more popular substituted ingredients in ephedra products since the FDA banned this alkaloid in 2004.
P-synephrine is found in this supplement in the form of citrus aurantium extract, otherwise known as bitter orange. This ingredient as acts as an adrenergic agent and is found in a huge number of thermogenic and weight-management products today.
Athletes have been known to use the product for not only enhanced energy, but stamina. It also has a reputation of providing mild appetite suppressing capabilities, increasing resting basal metabolic rate, and metabolic activity in the body.
It is difficult to assess the specific effect of p-synephrine on the body because other ingredients like caffeine are typically included in fat-burning and energy-enhancing products.
In some studies, an increase in blood pressure and heart rate have been noted with use of Bitter Orange extract, with or without combination with other forms of caffeine. While this supplement may promote some of the same positive effects as ephedrine, it may also promote some of the negative effects.
The manufacturer of Methyldrene 25 recommend its use with an appropriate diet and exercise plan. When used by itself, reviewers have stated that it produces a jolt of energy, but will not result in significant fat-burning effects over the long term unless calorie intake is decrease and activity level is increased.
Where Can I Buy Methyldrene 25?
Methyldrene 25 is available from a number of dietary supplements suppliers. Among them include:
- Ephedra Warehouse – cost of Methyldrene 25 Elite (100 capsules) averages $70, often found on sale. The “original” ECA stack (100 capsules) also averages $70
- A1 Supplements – original – averaging $30 for 100 capsules
- SameDaySupplements – 100 capsules, averaging $35, often found on sale
- TFSupplements – 100 capsules, averaging $70, often found on sale.
This supplement is not sold by larger retailers like Amazon, GNC, Walmart, Walgreens, Target, CVS, Costco, Rite-Aid or major grocery stories. Many of these retailers have decided against carrying ephedra diet pills, even if they are legal under FDA requirements.
While you may be able to find it in store at some smaller offline retailers where you live, availability varies from state to state.
Side Effects from Methyldrene 25
Side effects associated with Methyldrene 25 will depend on the user’s sensitivity or tolerance to stimulant ingredients like caffeine.
Some may experience a jittery, nervous sensation and a racing heartbeat, while others may not experience any adverse reactions.
This product is not appropriate for everyone. Even when taken as directed, some individuals may experience some temporary side effects including heart palpitations, headaches, nervousness, anxiety or upset stomach.
There is a greater risk of adverse effects from taking Methyldrene 25 among people who have been diagnosed with medical issues or anyone currenting using prescription drugs or other over-the-counter supplements.
Using this product with other stimulants, alcohol, caffeine, Monoamine Oxidase Inhibitor drugs or medications that affect blood pressure could result in serious side effects.
A specific warning was issued by the FDA regarding the ingredient methylsynephrine in 2016. According to a report posted on their website, “the substance does not meet the statutory definition of a dietary ingredient.”
According to a US FDA safety news release, Methyldrene 25 Ephedra Elite Stack manufactured by Cloma Pharma Laboratories is listed among the product names and manufacturers where questionable labeling and ingredient descriptions have been warned against. 
Cautions, Interactions, and Contraindications of Use
Energy-promoting and weight-loss products found on dietary shelves today are typically not intended for use by individuals under 18 years of age. A number of cautions and warnings do apply, as well as potential interactions with other drug products including prescription strength, over-the-counter herbal remedies, and dietary supplements.
Individuals diagnosed with any cardiovascular and metabolic condition should avoid use of ephedra or ephedra extract-containing products as well as other stimulants without first discussing use with their physician.
Ephedra products – whether they contain ephedrine alkaloids or not – are not recommended for pregnant or nursing women because potential effects on fetal development or infants have not been assessed.
In addition, ephedra and other stimulative components found in a number of dietary weight loss and energy-producing products may negatively interact with antidepressants (prescription as well as over-the-counter products), as well as diabetes medications due to its effect on metabolism and digestive processes.
Before using Methyldrene 25, take the time to research the ingredients found on the label. These ingredients may be able to support weight loss goals, but the benefits may not be worth the risk.
Both the Original Methyldrene 25 ECA Stack and the Elite version contain a number of stimulant ingredients that could cause adverse reactions. There are no research studies available to evaluate the specific effects of this combination of ingredients.
Many people use this supplement to boost their energy levels, help control hunger cravings and provide pre-workout athletic performance enhancement. However, long-term use and taking this product at high dosages may prove more negative than positive.
Any product that can increase heart rate can be dangerous, especially when not taken as directed or used for prolonged periods of time. While some people may be able to use this supplement safely, others may experience harmful reactions even at suggested serving sizes.
Before using Methyldrene 25, consult with a physician to determine whether this product is appropriate for you. Make sure that your physician is aware of any health conditions you have or medications or supplements you are currently taking.