Lipodrene with ephedra is marketed as a “The World’s Most Advanced Weight Loss Aid Ever Developed.”
Lipodrene is a fat-burning supplement manufactured by Hi-Tech Pharmaceuticals. The original version of this supplement contained ephedrine alkaloids and was banned in 2004 by the FDA.
The new version of this supplement uses ephedra extract without ephedrine. This product also contains other ingredients that are purported to enhance metabolism and boost energy levels.
How does the new version of Lipodrene with ephedra extract compared to other weight loss products and is this supplement safe? In this review, we will discuss the ingredients, effects, benefits and potential side effects of using Hi Tech Lipodrene. Click here to buy ephedra supplements online legally without a prescription.
Lipodrene with Ephedra Product Description
Lipodrene with ephedra is advertised as “The #1 Selling Weight Loss Product in America with Ephedra.”
It is designed as a fat-burning thermogenic supplement with appetite suppressant effects. This supplement is purported to promote weight loss by stimulating the metabolism and boosting energy levels.
This product is also promoted as containing 25mg of Thermo-Z™ brand Ephedra Extract which, according to the manufacturer, is “Legal in All 50 States”.
You may be wondering how this supplement is still legal to buy in the USA following the 2004 ban on ephedra alkaloids from dietary supplements. After this ban, the supplement was recalled and had to be reformulated.
The FDA’s ban specifically targeted supplements that contained the ephedrine alkaloids. This is the main active ingredient in the ephedra plant. You can learn more about the difference between ephedrine and ephedra here.
The Lipodrene product (and all other ephedra supplements sold today in the USA) contains a version of this herbal extract with no ephedrine alkaloids. You can think of this like drinking coffee without the caffeine alkaloid.
While decaffeinated coffee does have some physiological effects, it does not boost energy or alertness in the same was as caffeinated coffee. Similarly, ephedra extract with no ephedrine will not increase metabolism to the same degree as the full spectrum extract.
To account for this reduction in potency, Hi-Tech Pharmaceuticals has added several other stimulants to this product with similar mechanisms of action. For example, green tea extract, synephrine, theobromine and senegalia berlandieri extract are all purported to enhance fat loss results.
How effective is the new version of Lipodrene with ephedra extract and how is this new supplement supposed to work?
Benefits and Effects
The manufacturer states that the new version of this product is as good as the original. User reviews left on the Hi-Tech Pharma website are generally positive and rate it well in regard to its appetite suppressant capability.
According to the makers of Lipodrene, this supplement reduces food cravings, helping users to cut calorie intake. From user comments, it may cause nausea or stomach upset in some individuals.
Users also say that it has benefits for energy enhancement, making it easier to work out and boosting motivation to exercise. Some find it to be over-stimulating and recommend taking a smaller dosage.
As a thermogenic supplement, Lipodrene is intended to boost metabolic rate so that users burn more calories throughout the day. This is believed to support weight loss without changing exercise habits; however, better results will be achieved in conjunction with diet and exercise.
The original Lipodrene diet pills worked because they contained ephedrine, which is a Central Nervous System stimulant that affects the body in a similar way to adrenaline. It activates beta-2 adrenergic receptors and promotes the release of norepinephrine.
This causes your body to break down more stored fats to burn for fuel. A byproduct of this activity is increased heat generation, which can moderately raise core body temperature.
Even though the newer version of Lipodrene does not contain ephedrine, it does contain a number of herbal supplements that are touted as legal alternatives to this fat-burning plant alkaloid.
Ephedra Extract Supplements
While Lipodrene does contain ephedra extract, it does not mention what species of the plant that extract comes from. The portion of the plant used to manufacture the extract – fruit, leaves, stems, or the roots – can also have an influence on potency.
Ephedra is a plant genus identified as belonging to the Ephedraceae family. Dozens of different species of ephedra are found growing in dry, desert-like regions around the world, mainly in Asia, North Africa, the Mediterranean, the American southwest and in Mexico
In Chinese herbal medicine, ephedra has been used for thousands of years as a treatment for lung conditions such as asthma, bronchitis, or sinusitis. The ephedra sinica (Chinese Ma Huang) plant contains numerous alkaloids with medicinal properties including :
- Pseudoephedrine (isoephedrine)
- Norpseudoephedrine (cathine)
Ephedrine is the strongest of these alkaloids in promoting stimulation of the central nervous system. It affects respiration, circulation, heart rate, digestion, metabolism and hormone balance.
Not all forms of ephedra contain this alkaloid. For example, the Ephedra viridis or E. nevadensis species which are native to the southwestern United State contain little to no alkaloids.
Ephedrine alkaloids have been banned in dietary supplements by the U.S. FDA due to their potential for serious and often life-threatening side effects. However, ephedra extract with no ephedrine alkaloids is legal to use as an ingredient and does not pose adverse cardiovascular risk.
The new version of Lipodrene from Hi-Tech Pharma uses a form of the plant that does not contain the active alkaloids. This makes it legal to sell in the USA, but also means it has limited efficacy for weight loss on its own.
While Lipodrene is technically an ephedra supplement, this is not what makes it effective for weight loss. It is the other ingredients in this product that work to stimulate greater calorie expenditure. Ingredients listed on the label include:
- 25 mg ephedra extract (leaves)
- 100 mg caffeine anhydrous
- Senegalia Berlandieri extract (yielding 225mg Phenylethylamine alkaloids including Phenylethylamine, Methylsynephrine, N-Methyl-B-Phenylethylamine, N,N-Dimethylphenylethylamine)
- Synephrine HCl
- Naringen (fruit)
- Cassia Nomame Extract (plant)
- 5-Methoxytryptamine HCl
- Hoodia extract (cactus)
- 6,7,Dihydroxybergamottin (fruit)
- Yohimbine HCl
- Green tea extract (45 mg EGCG)
Caffeine, synephrine, yohimbine, green tea extract and theobromine all work as stimulants that can increase energy levels. 5-HTP and Hoodia extract are appetite suppressants that can reduce hunger cravings.
Senegalia Berlandieri is promoted as a legal alternative to Acacia Rigidula extract, another banned ingredient that was formerly used in Lipodrene and other Hi-Tech supplement. This supplement is described as a source of stimulating phenylethylamine alkaloids.
However, there are no research studies available online describing the effects of Senegalia Berlandieri extract. More research is needed to evaluate the safety and efficacy of this product for weight loss.
Furthermore, the ingredients found in the Lipodrene supplement form a 560mg proprietary blend called Thermo-Rx and Extend-Rx. Dosages for the specific ingredients in these blends are not disclosed, which makes it difficult to rate the potential effects.
Recommendations for Use
According to the product label, it is recommended to take one to two tablets in the morning and one tablet after lunch. Users are cautioned against exceeding four tablets a day.
Some users recommend splitting this dosage into half or one-quarter, depending on individual sensitivity to stimulants. Users who have a low tolerance to the effects of caffeine should start with a half-dose to gauge their reaction.
Ephedra and other stimulants have the potential to cause serious side effects and adverse reactions, even at lower dosages. Use of this supplement may not be safe for everyone.
A number of factors can affect how a person reacts to this product including:
- Body composition
- Height and weight
- Diet and lifestyle
- Exercise programs
- Frequency of usage
Do not take ephedra extract supplements without first consulting with a doctor. Get approval from your doctor before using if you have been diagnosed with a medical condition or are currently using prescription or over-the-counter medications.
It is advised to drink lots of water with this product. Do not take it late in the day as it can cause insomnia or sleep disruptions. Combining Lipodrene ephedra pills with other stimulants may increase the risk of side effects.
User reviews for Lipodrene posted online are generally positive, but not everyone will respond in the same way to this product. There are also several negative reviews from individuals saying this supplement was too strong for them.
Different individuals can react differently to the effects of this supplement. Even individuals with the same body composition and fitness level may react differently to any particular product.
One of the more popular retailers that carries this supplement is Ephedra Warehouse. There are 162 user reviews left by people who took Lipodrene on this site, most with ratings of four to five stars.
Some claim benefits for weight loss without any of the jitteriness common with ephedra products. Others claim that it worked as an appetite suppressant and helped reduce caloric intake, but also caused upset stomach and headache.
Other state that Lipodrene promoted greater energy levels which made workout out at the gym easier. Several users stated that the energy boost had benefits in day-to-day activities as well.
Some reviewers stated that while the product did work, the effects only lasted an hour or two after taking the initial recommended dose. Some users describe feeling sick after the effects wear off.
Negative reviews typically describe side effects like jittering, racing heart, runny nose, nausea, with some experiencing vomiting. Others complained about difficulty sleeping, while others found the mixture caused too much anxiousness.
One user wrote, “I haven’t been eating right definitely can not sleep, I got weird dark orange urine bad headaches very aggressive behavior and agitated,up and down with energy, not very good for me.”
A number of possible side effects can occur when taking Lipodrene with ephedra, even at the recommended dosages. Some people are more sensitive to the stimulatory ingredients.
There have not been any clinical studies conducted on Lipodrene to evaluate safety. While many of the ingredients have been studied in isolation, it is difficult to determine how these ingredients may affect one another in combination.
Some of the commonly reported adverse effects in user reviews include:
- Upset stomach/nausea, sometimes with vomiting
- Jitteriness (varies in severity)
- Trembling of the hands
- Heart palpitations
- Heightened sense of anxiety or restlessness
- Difficulty concentrating or focusing
- Difficulty sleeping or insomnia..
Adverse effects are more likely when taken in high dosages or if used on an empty stomach. It is recommended to take this product with meals and drink plenty of fluids to prevent some side effects.
If you experienced impaired sleep quality or delayed sleep onset, avoid using this product after mid-afternoon. Avoid combining with other stimulants and check with a doctor before using it with additional dietary supplements or herbal remedies.
Ephedrine was banned from dietary supplements due to a high risk of serious side effects. Taking more than 32mg of this plant extract daily could triple the risk for brain hemorrhage, stroke, heart attack and other cardiovascular events. 
Some recent studies have examined the effects of ephedra without the ephedrine or pseudoephedrine alkaloids. In animal studies, use of ephedra extract without the alkaloids was found to be safe and effective for certain therapeutic targets. 
Human studies are focusing on the use of alkaloid-free forms of ephedra extract for analgesic effects, and immune-boosting properties.  One multicenter trial involving 300 patients is currently ongoing.
However, this does not mean that all ephedra extract supplements with the ephedrine alkaloids removed will be safe. Consumers should carefully weigh the benefits of use against the potential for dangerous side effects, especially if the product contains other herbal stimulants.
Safety of Lipodrene Ingredients
There are concerns about the use of ephedra extract supplements with high dosages of caffeine or other stimulants such as Bitter Orange (Citrus aurantium).
Bitter Orange contains the alkaloid p-synephrine, which has a similar mechanism of action to ephedrine. This component is popular in weight loss supplements, marketed for its ability to increase mental focus, suppress the appetite, boost energy and enhance metabolism.
P-synephrine stimulates adrenergic receptors in a similar fashion to ephedrine but is less potent and does not affect all of the same receptors. To date, this effect has mainly been studied in animals and there is limited research into the weight loss potential of Bitter Orange extract.
Research shows that synephrine is safer than ephedrine and is relatively well-tolerated in appropriate dosages. However, it is uncertain whether high doses of this ingredient in combination with other stimulants may cause serious adverse reactions.
At a maximum dose of 49 mg, p-synephrine does not cause negative cardiovascular side effects.  In supplements with high doses of caffeine and other stimulants, there may be a greater risk for negative effects.
Until large-scale studies on humans have been conducted, it is recommended that individuals proceed with caution when using ephedra extract products, including Lipodrene.
Individual diagnosed with a medical condition or using any prescription drugs or over-the-counter medications should consult with their pharmacist or their physician before using. A qualified medical practitioner can help you learn about potential interactions and contraindications for use.
Where To Buy Lipodrene Online
There are a number of different websites that sell Lipodrene with ephedra. However, many major retailers like Amazon, Walmart, GNC, Walgreens, iHerb and CVS do not carry this supplement.
Hi-Tech Pharmaceuticals currently sells six different products with the Lipodrene brand name. These include:
- Lipodrene Elite
- Lipodrene Ephedra-Free
- Lipodrene Hardcore with Ephedra
- Lipodrene Hardcore Ephedra-Free
- Lipodrene Xtreme V2
The original Lipodrene with 25mg Ephedra Extract supplement is typically sold in a 100-count bottle, but there is also a 20-count bottle available. Some of the popular vendors of this product are listed below:
NeutraSource: 100 count bottle sells for $39.95. Shipping charges apply.
Ephedra Warehouse: 100 count bottle sells for $39.95 with free shipping on orders of greater than $50.
My Supplements Store: 100 count bottle sells for $34.95 with free shipping on orders over $50 in the Continental USA. Their shipping guidelines specify that they do ship to over 120 countries around the world, but consumers may have products confiscated at international borders.
i-Supplements: 100 count bottle sells for $34.99 with a $6.95 flat shipping fee on orders under 2 pounds.
A1 Supplements: 100 count bottle sells for $34.95 Shipping charges apply.
Hi-Tech Pharmaceuticals: The Hi-Tech Pharmaceuticals website lists both the 100-count and 20-count tablet bottles as Out of Stock at present.
Best Price Nutrition: 100 count bottle sells for $34.95. Shipping charges apply depending on delivery method and location. Domestic US shipping starts at $5, although shipments to Alaska and Hawaii are higher. The website does offer valuable information in regard to shipments to countries around the world with the typical warnings regarding border controls and confiscations of product.
Black Diamond Supplements: 100 count bottle sells for $34.95. Free shipping on orders above $99.
Note: Those purchasing Lipodrene with ephedra from international countries should be aware of any duties, customs fees and taxes that may be charged upon receipt.
If the purchaser refuses to pay these charges, the package will be returned. Retailers may provide you with a refund on the purchase price, minus the return shipping costs.
Some products may be confiscated or seized at the border, depending on where you live. Retailers may not provide refunds in such cases. Check with each individual supplier before deciding to buy this product and mail it internationally.
Before ordering Lipodrene online, take the time to research the reputation of the seller and seek out feedback from other customers. Make sure to purchase from a supplier with a return policy stated clearly on their website.
Lipodrene with ephedra may provide benefits for weight loss, energy and appetite control. However, it may cause side effects in some users and is not recommended for everyone.
This product has gone through multiple reformulations to remove banned ingredients, including ephedra with ephedrine alkaloids, DMAA and Acacia Rigidula. The currently available formula may be different from the one reviewed in this article.
As a fat burner, Lipodrene is not designed to work all by itself, but is intended to be used in combination with a balanced diet and adequate exercise.
Because tolerance among individuals is so varied it is recommended that anyone wanting to try Lipodrene with ephedra start at the lowest possible dosage to see how the body reacts to it.
For some, usage of products like Lipodrene with ephedra may cause more side effects than the overall benefits of use.
- Sigma-Aldrich. Ephedra (Ephedra sinica)
- RxList. Ephedra.
- Odaguchi H. Clinical Research Testing Usefulness of Ephedrine Alkaloids-free Ephedra Herb Extract. Yakugaku Zasshi 2017;137(2):195-197. doi: 10.1248/yakushi.16-00233-6.
- Hyuga S. The Pharmacological Actions of Ephedrine Alkaloids-free Ephedra Herb Extract and Preparation for Clinical Application. Yakugaku Zasshi 2017;137(2):179-186. doi: 10.1248/yakushi.16-00233-4.
- Shara M, Stohs SJ, Mukattash TL. Cardiovascular Safety of Oral p_Synephrine (Bitter Orange) in Healthy Subjects: A Randomized Placebo-Controlled Cross-over Clinical Trial. Phytother Res. 2016 May;30(5):842-7. doi: 10.1002/ptr.5590. Epub 2016 Mar 7.